Unique suites of available polysaccharides, a theme that likely applies to disparateīacteria from the gut and other habitats.īacteria inhabiting the human gut are critical for digestion of the plant-derived Species have diverged into different carbohydrate niches by evolving genes that target

These results provide a view of how these Specific for a defined cell wall polymer. Provide the regulatory cues that induce PUL activation and that each PUL is highly Systems in conjunction with transcriptional analyses demonstrate that complex oligosaccharides Binding studies of the purified sensor domains of PUL-associated hybrid two-component O-glycans, a phenotype that is undetectable inī. thetaiotaomicron genome has been shaped by increased numbers of PULs involved in metabolism of host ovatus possesses several unique PULs that enable degradation of hemicellulosic polysaccharides,ī. Individual Sus-like systems that target various plant polysaccharides. The identity and specificity of the polysaccharide utilization loci (PULs) that encode Transcriptional profiling and gene inactivation experiments revealed Rhamnogalacturonan II, a highly complex polymer thought to be recalcitrant to microbialĭegradation. ovatus, are capable of utilizing nearly all of the major plant and host glycans, including However, the role of these systems in degrading the chemicallyĭiverse repertoire of plant cell wall glycans remains unknown.

These species useĪ series of membrane protein complexes, termed Sus-like systems, for catabolism of Phyla in the adult gut, possess broad glycan-degrading abilities. The Bacteroidetes, one of two dominant bacterial Polysaccharides are not digested by human enzymes, but are processed to absorbable Utilize complex carbohydrates, primarily plant cell wall glycans in our diets. Symbiotic bacteria inhabiting the human gut have evolved under intense pressure to

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